Structural genomics involves taking a large number of approaches to structure determination, including experimental methods using genomic sequences or modeling-based approaches based on sequence or structural homology to a protein of known structure or based on chemical and physical principles for a protein with no homology to any known structure.As opposed to traditional structural biology, the determination of a protein structure through a structural genomics effort often (but not always) comes before anything is known regarding the protein function.A 'protein sequence ontology' to facilitate comparison of the annotations has also been developed (G Reeves, personal communication).
Louis Guenther, Alex; University of California, Irvine Basu, Chhandak; Biology, California State University, Northridge Abstract: Rise in air pollution has led to increasing cancer, several respiratory and cardiac illnesses in humans.
The investigation of sequence-function and structure-function relationships has therefore become a fundamental necessity.
Understanding these relationships will be crucial for moving from an inventory of protein parts to a more profound understanding of the molecular machinery of organisms at a systems level. DAS allows different laboratories to 'combine' their annotations, produced by both experimental and computational approaches, to generate a 'composite' annotation at all levels.
World Health Organization estimates that one in eight person die from air pollution.
The main objective of our study is to analyze the feasibility of genetically engineered plants to remove polluting volatile compounds from air.